Hydroxyprogesterone caproate is a synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate.
- Mechanism
- Curator reviewed
The mechanism by which progesterone prevents preterm birth is not well understood, but many pathways are likely involved. Progesterone plays a vital role in regulation of the female reproductive system and is important for successful implantation of the embryo and maintenance of pregnancy. It acts by binding to progesterone receptors in the uterus, ovaries, breasts and in the central nervous system. These receptors exist in 2 isoforms, PR-A and PR-B. Progesterone binding to these receptors ultimately leads to regulation of gene transcription. This results in an anti-inflammatory effect which blunts the proinflammatory state that occurs with initiation of labor, and maintains uterine queiscence by stabilizing progesterone acting on the myometrium.
- Primary indication
- Hydroxyprogesterone caproate was previously indicated in the US for the prevention of spontaneous preterm births in singleton pregnancies in women with a history of spontaneous preterm birth.Curator reviewed · 4 structured indications
- Formula / weight
- C27H40O4 · 428.6041 g/mol (avg)
- First approval
- United States, 2011
- Also known as
- 17 alpha-hydroxyprogesterone caproate · 17 Hydroxyprogesterone Capronate · 17-alpha hydroxyprogesterone caproate · Hydroxyprogesterone hexanoate
- Code names
- NSC-17592
- Brand names
Resolves to
DOMWKUIIPQCAJU-LJHIYBGHSA-NSMILES[H][C@@]12CC[C@](OC(=O)CCCCC)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CWhat you can answer from here — as of June 15, 2026
Which drugs share a target with Hydroxyprogesterone caproate, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account